When should I invest in Betta Pharmaceuticals?
Make sure it's a Monday before you start the mission, then invest all of each character's money into Betta Pharmaceuticals via the BAWSAQ site.
Grand Theft Auto 5 GTAV - Buy Betta Pharmaceuticals!!! | WikiGameGuides
After completing the mission, wait around 3 days as the shares rise their value then sell them to cash out a huge profit margin.
Hotel Assassination
Sell Betta Pharmaceuticals (50% profit) after the mission. Save the game by sleeping to accelerate time. After waiting for three days or more, purchase Bilkinton Research (LCN). Then wait for at least a week and sell it before the next mission.
The first mission given to Franklin by Lester tasks him with taking out Brett Lowrey of Bilkinton Research. Before stepping into the marker, GTA 5 players should switch to all characters and invest everything into Betta Pharmaceuticals. After the mission, they should sell the stocks when the max return reaches 50%.
Beta Pharmaceuticals (BET) can reach an 80% ROI, Façade (FAC) a 160% ROI, Redwood Cigarettes (RWC) a 300% ROI, Vapid (VAP) a 20% ROI, and Gold Coast Construction (GDC) a 180% ROI. Each of these stocks provides valuable returns for completing specific assassination missions.
Summary: Prior to « The Multi-Target Assassination » have all your characters invest into Debonaire (DEB) Cigarettes, Redwood's rival, until your return on investment is around 100% (highest possible is 103.27%).
If you were successful, all three of the protagonists - Franklin, Trevor, and Michael - will have an extra $400,000 to be used for investments, and if you use that to buy up the now-dirt cheap Bilkington stock, the final payout from all of the investment assassinations at the end of the game will be boosted by ...
The Multi-Target Assassination
In this assassination you are damaging the shares of Redwood in order to raise the shares of Debonaire. You may have to wait a few days for Redwood to rebound, so just keep sleeping until it peaks (usually 48 hours).
While you can make good money paying attention to which stocks rise and fall and selling at the opportune moment, the best moment to trade stocks is when completing Franklin's five Stock Market Assassination Missions.
Why is the BAWSAQ market down?
GTA 5 Bawsaq Network Down For Maintenance Fix - YouTube
For this mission, you will need to buy GoldCoast (GCD) stocks before you take the mission. Once it is completed, sell the stocks after they rise on the LCN to about 80% return percentage.
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Invest all money in it prior to completing "Meltdown", then quickly complete the mission "The Big Score". After completing "The Big Score" FlyUS stock should yield a 100% return; invest all money made from "The Big Score" in it. Wait for FlyUS stock to yield a 158% return, then sell all of it.
Stock Tip. In order to maximize profits, don't sell the $100,000 right away. Keep an eye on the market as you progress the main story. You can get a profit as high as 30% or more from the original investment made by Gray.
After you kill Bret Lowery of BETTA PHARMACETICALS, wait about 2-3 in-game days and watch the stock market as the shares of BILKINTON (BIL) (LC'N) plummet.
Stock Tip. After completing The Hotel Assassination mission, Bilkinton's price in the stock market will have a major drop, so it is recomended that the player buy Bilkinton's stocks after the mission is finished and wait 2-3 days until their price return to the pre-assassination level, for a tidy profit.
When it goes down into the bottom of the trading range, buy it. Then when it goes up to the top, sell it! Note that the stock in question for your game will not be one affected by the Assassination Missions (ie Debonaire Cigarettes, Redwood or GoldCoast).