The 'blue baby' syndrome is related to Excess of TDS (total dissolved solid)Excess of chlorideMethemoglobinExcess of dissolved oxygen (2024)

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The 'blue baby' syndrome is related to Excess of TDS (total dissolved solid)Excess of chlorideMethemoglobinExcess of dissolved oxygen? ›

A blue baby syndrome is caused by methemoglobinemia. It is caused by nitrate contamination in groundwater resulting in decreased oxygen carrying capacity of haemoglobin in babies leading to death.

Blue baby syndrome beings when large amounts of nitrates in water are ingested by an infant and converted to nitrite by the digestive system. The nitrite then reacts with oxyhaemoglobin (the oxygen-carrying blood protein to form methaemoglobin, which cannot carry oxygen)

Blue baby syndrome is a rare condition that occurs when infants drink formula that has been made with water contaminated by high levels of nitrates.

It begins when large amounts of nitrates in water are ingested by an infant and converted to nitrite by the digestive system. These nitrites bind to the hemoglobin in the body, forming methemoglobin, which is unable to carry oxygen. This syndrome occurs due to a decreased amount of hemoglobin in the baby's blood.

Abstract. The use of nitrate-contaminated drinking water to prepare infant formula is a well-known risk factor for infant methemoglobinemia. Affected infants develop a peculiar blue-gray skin color and may become irritable or lethargic, depending on the severity of their condition.

Acquired methemoglobinemia may be due to exposure to direct oxidizing agents (e.g. benzocaine and prilocaine), indirect oxidation (e.g. nitrates), or metabolic activation (e.g. aniline and dapsone).

(MET-hee-moh-GLOH-bih-NEE-mee-uh) A condition in which a higher-than-normal amount of methemoglobin is found in the blood. Methemoglobin is a form of hemoglobin that cannot carry oxygen. In methemoglobinemia, tissues cannot get enough oxygen.

“Central cyanosis” refers to cyanosis found on “central” parts of the body, including the mouth, head and torso. Central cyanosis is never normal in the newborn period and is almost always linked to a lower amount of oxygen in the blood. It could be due to a problem of the heart, lungs or blood.

The most common symptom of cyanosis is blue skin, especially where the skin is thin, such as the mouth, lips, fingernails, and earlobes.

Over 90 percent of those operated on for congenital heart defects as children, for example, due to blue baby syndrome, are alive 20 years post-surgery. A new doctoral thesis at Sahlgrenska Academy has explored this issue.

How was blue baby syndrome cured? ›

Until the day of that milestone blue baby operation, most infants and children with the heart defect died. This surgery was deemed a success, thanks to implantation of the new shunt, which increased blood flow, allowing enough of it to pass through the lungs and pick up more oxygen.

The most common cause of congenital methemoglobinemia is cytochrome b5 reductase deficiency (type I b5R). This enzymatic deficiency is endemic in certain Native American tribes (Navajo and Athabaskan Alaskans). Most cases of methemoglobinemia are acquired and result from exposure to certain drugs or toxins.

Consuming too much nitrate can be harmful—especially for babies. Consuming too much nitrate can affect how blood carries oxygen and can cause methemoglobinemia (also known as blue baby syndrome). Bottle-fed babies under six months old are at the highest risk of getting methemoglobinemia.

Babies born too soon (premature) or those who did not get enough oxygen during birth may have permanent injury. This may affect their brain, heart, lungs, kidneys, bowels or other organs. Babies with asphyxia may develop: Cerebral palsy.

A blue baby syndrome can be caused by methemoglobinemia. It is caused by nitrate contamination in groundwater resulting in decreased oxygen carrying capacity of haemoglobin in babies leading to death.

1. Blue lips (cyanosis) “If your baby's lips are turning blue, or the mucus membranes in their mouth or tongue turn blue, this is a sign that they are not getting enough oxygen,” says Carrie Drazba, MD, a pediatrician at Rush University Medical Center in Chicago. This condition is known as cyanosis.

Blue baby syndrome has been attributed to cyanotic congenital heart diseases and methemoglobinemia, however there are additional causes that could result in a baby becoming cyanotic, such as: Airway obstruction. Decreased blood perfusion. Disordered control of breathing (ex: Cyanotic breath-holding spells, seizures)

The most common cause of congenital methemoglobinemia is cytochrome b5 reductase deficiency (type I b5R). This enzymatic deficiency is endemic in certain Native American tribes (Navajo and Athabaskan Alaskans). Most cases of methemoglobinemia are acquired and result from exposure to certain drugs or toxins.

Benzodiazepine intake during early pregnancy may be teratogenic, and their intake during late pregnancy may be associated with neonatal withdrawal syndrome and 'floppy infant' syndrome.