Insurance Coverage for Corneal Cross-Linking in the U.S. (2024)

Insurance Coverage for Corneal Cross-Linking in the U.S. (1)

What is corneal collagen coss-linking for keratoconus?

Corneal collagen cross-linking is a treatment for keratoconus. In corneal coss-linking, doctors use eyedrop medication and ultraviolet (UV) light from a special machine to strengthen the tissues in your cornea. The procedure involves applying specially formulated riboflavin (vitamin B2) eyedrops to your cornea, which allow it to better absorb light. After about 30 minutes, you’ll look up at a light while lying back in a chair. The entire treatment takes about 60-90 minutes.

The procedure doesn’t reverse cornea changes that have already happened – it just keeps them from getting worse. Since it can help slow progression, it’s best to talk to your doctor sooner than later if you have keratoconus.

How much does Crosslinking for Keratoconus cost?

There is limited evidence on the costs of corneal crosslinking, but it may be as high as $2,500 to $4,000 per eye in the United States. a cost-effectiveness study estimated the costs of the total treatment for one person as £928 in the UK National Health Service.

Is crosslinkig for keratoconus covered by health insurance?

Since FDA approval of corneal collagen crosslinking (CXL) for keratoconus in April 2016, many insurance companies have started covering this procedure for progressive keratoconus and keratectasia.

Where in the United States is crosslinkig for keratoconus covered by health insurance?

All 50 states have six or more health insurance plans that cover the FDA-approved corneal cross-linking for keratoconus.

Which corneal crosslinking method is covered?

FDA has approved corneal collagen crosslinking (CXL) for progressive keratoconus in April 2016. this approval only covers the crosslinking products developed by Glaukos Corporation (formerly Avedro, Inc.).

This FDA-approved method involves corneal epithelial debridment, hence it is known as epithelium-off or epi-off crosslinking. At this time, epi-on crosslinking method is not approved by FDA and thus it is not covered.

What are the drugs and devices used in the FDA-approved corneal cross-linking?

FDA-approved corneal cross-linking uses the drugs and device manufactured by Avedro. In order to be eligible for insurance reimbursem*nt, your procedure must consist of the KXL System and Photrexa drug formulations. These are the only cross-linking drugs and device that are FDA-approved and eligible for insurance reimbursem*nt in the United States.

What is the CPT code for corneal collagen crosslinking?

Category III CPT 0402T: Collagen crosslinking of cornea, including removal of the corneal epithelium and intraoperative pachymetry when performed.

CPT Category III codes represent temporary codes for new and emerging technologies. They have been created to allow for data collection and utilization tracking for new procedures or services. With this Category III code the individual payers will decide whether to cover the procedure.

Does Photrexa® Viscous and Photrexa® have product specific J-code?

J-code J2787 has been issued by the Centers for Medicare and Medicaid Services for the use of Photrexa® Viscous (riboflavin 5’-phosphate in 20% dextran ophthalmic solution) and Photrexa® (riboflavin 5’-phosphate ophthalmic solution) formulas.

Below is an updated list of insurance companies in United States that cover corneal collagen crosslinking (CXL) for progressive keratoconus:

Payer NamePayer Region
AetnaNational
AllWays Health PartnersMA
AmeriHealthDE, NJ, PA
AnthemNational
Arkansas Blue Cross Blue ShieldAR
BCBS Health AdvantageAR
BCBS of North DakotaND
BCBS of VermontVT
Blue Cross Blue Shield FEPNational
Blue Cross Blue Shield of AlabamaAL
Blue Cross Blue Shield of ArizonaAZ
Blue Cross Blue Shield of FloridaFL
Blue Cross Blue Shield of GeorgiaGA
Blue Cross Blue Shield of IllinoisIL
Blue Cross Blue Shield of KansasKS
Blue Cross Blue Shield of Kansas CityKansas City, Northwestern MO, Johnson & Wyandotte Counties
Blue Cross Blue Shield of LouisianaLA
Blue Cross Blue Shield of MassachusettsMA
Blue Cross Blue Shield of MichiganMI
Blue Cross Blue Shield of MinnesotaMN
Blue Cross Blue Sheild of MississippiMS
Blue Cross Blue Shield of MontanaMT
Blue Cross Blue Shield of New MexicoNM
Blue Cross Blue Shield of North CarolinaNC
Blue Cross Blue Shield of North DakotaND
Blue Cross Blue Shield of OklahomaOK
Blue Cross Blue Shield of Rhode IslandRI, CT, MA
Blue Cross Blue Shield of South CarolinaSC
Blue Cross Blue Shield of TennesseeTN
Blue Cross Blue Shield of TexasTX
Blue Cross and Blue Shield of VermontVT
Blue Cross of IdahoID
Blue Shield of CaliforniaCA
BlueChoice Health Plan of South CarolinaSC
Capital Blue CrossCentral PA
Capital Health PlanFL
CareFirst Blue Cross Blue ShieldMD, DC, Northern VA
Cigna HealthNational
ConnectiCareCT
Dean Health PlanWI
Emblem HealthNY
Empire Blue Cross Blue ShieldNY
Fallon HealthMA
Geisinger HealthPA, DE, ME, NJ, WV
Harvard PilgrimMA
Hawaii Medical Service AssociationHI
Health Alliance Plan of MichiganMI
Health New EnglandMA
HealthNetCA, AZ
HealthPartners MinnesotaMN, ND, SD, WI
Highmark Blue ShieldDE, PA, WV
Horizon Blue Cross of New JerseyNJ
HumanaNational
Independence Blue CrossPA, NJ, DE, MD
John Hopkins HealthCareMD
Kaiser PermanenteAZ, CA, CO, DC, GA, HI, MD, NV, TX, VA, WA
Medica Health PlansMN, WI, ND, SD
Medical MutualOH
Moda HealthOR
Nebraska BlueNE
Premera Blue CrossWA, OR, AK
Presbyterian HealthNM, AZ, CO, TX
Priority Health of MichiganMI
Providence Health PlanOR, WA
Public Employee Health Plan (PEHP)UT
Quartz - Unity HealthWI
Regence Blue Cross Blue ShieldID, OR, UT, WA
Rocky Mountain Health PlansCO, NE
Scott & White Health Plan (SWHP)TX
Select HealthID, UT
TricareTRICARE Policy Manual: Rare Diseases, Eye And Ocular Adnexa, Available to all Tricare beneficiaries, including dependents. also see this comment.
Tufts Health PlanMA, RI
United HealthcareNational
Wellmark Blue Cross and Blue ShieldIA, SD
This list is subject to change. It is not intended to be a directive, nor is it a suggestion about the likelihood of coverage or reimbursem*nt. Please confirm with your individual carriers.

Reimbursem*nt questions and financial assistance

The iPath360 program by Glaukos is a service to help keratoconus patients with reimbursem*nt questions, prescription assistance and the possibility of financial assistance for eligible patients.

Call the iPath360 hotline 844-528-3311 for questions about coding, billing, claims submissions or payer coverage for corneal cross-linking with Photrexa® Viscous and Photrexa® with the KXL® System.

Visit iPath360's website and Avedro's website to learn more about insurance coverage and find resources and cornea specialist who perform corneal crosslinking.

Learn more about corneal collagen crosslinking (CXL)

Insurance Coverage for Corneal Cross-Linking in the U.S. (2024)

FAQs

Insurance Coverage for Corneal Cross-Linking in the U.S.? ›

There are two types of corneal cross-linking: epithelium-off cross-linking and epithelium-on cross-linking, but only epithelium-off cross-linking is presently FDA approved. This means that insurance companies will usually cover epithelium-off cross-linking, but they almost never cover epithelium-on cross-linking.

Is corneal crosslinking covered by insurance? ›

Upwards of 95% of medical insurances cover corneal cross-linking. Medical insurance is also valuable if your keratoconus is advanced to the level of needing corneal transplantation. By comparison, a vision plan can help you get the specialty contact lens prescribing needed for optimal vision.

How much does crosslinking cost in the US? ›

Corneal Cross Linking Cost

The average cost of a corneal cross-linking procedure typically ranges from $2,500 to $4,000 per eye.

Does VSP cover corneal cross-linking? ›

VSP and EyeMed do not cover corneal crosslinking but Care Credit, HSA and FSA can be used for these procedures. INTACS: Corneal INTACS implants are sometimes covered by health insurance provided the proper documentation that the procedure is medically necessary.

How do you bill corneal cross-linking? ›

The best way to do this is to submit a predetermination for both 0402T Collagen cross-linking (including removal of the corneal epithelium and intraoperative pachymetry when performed) and J3490 Unclassified drug.

Why is cross-linking not covered by insurance? ›

Insurance does not typically cover products and procedures that have not received FDA approval. The only FDA-approved products for cross-linking are from Avedro, and are performed epi-off.

How much does cross-linking for keratoconus cost? ›

If I do not have insurance, what does corneal crosslinking cost? If your insurance plan does not cover corneal crosslinking (or you are without insurance), corneal cross-linking can cost between $2,500 to $4,000 per eye.

Is crosslinking covered by Medicare? ›

However – according to the American Academy of Ophthalmology (AAO) – corneal cross-linking is only covered if an FDA-approved method (with concomitant approved medication) is utilized. Both Medicare Parts A and B only cover 80 percent of healthcare costs.

What is the success rate of corneal cross-linking? ›

The corneal cross-linking success rate is 95%. For the 5% of patients who don't respond to treatment, this is usually due to underlying health conditions disrupting the recovery process.

Is corneal cross-linking worth it? ›

Even so, some studies suggest that people really do see better after cross-linking. In a 2014 study, researchers found that about half of people who had cross-linking had an improvement of one line in visual acuity two years after surgery.

Does Aetna cover corneal cross-linking? ›

While cross-linking is not covered by all commercial plans, there has been a significant increase in the number of plans that do cover it, including most of the Blue Shield plans, Aetna (i), and Kaiser Permanente (ii). A full list of payers with positive coverage policies is available at www.livingwithkeratoconus.com.

Is keratoconus surgery covered by insurance? ›

Thankfully, most costs associated with keratoconus usually are covered by health or medical insurance. In particular, medical insurance typically covers most of the cost of corneal cross-linking or major keratoconus surgery (less deductibles and copays determined by your policy).

Does vision improve after corneal cross-linking? ›

Many research studies have shown that CXL may prevent further vision loss in over 95% of patients and improves vision in 60-81% of patients treated.

Who is a good candidate for corneal cross-linking? ›

Other requirements to be a good candidate for corneal cross-linking include: Eyes that are otherwise healthy and free from disease. Good general health, with no autoimmune disorders. No corneal scarring.

Can you get corneal cross-linking twice? ›

Yes. Corneal crosslinking is a highly effective FDA-approved treatment to stop the progression of keratoconus. If there is continued progression of the disease despite the first procedure, it can be repeated. Unfortunately, there are cases where the disease progresses despite repeat crosslinking.

How long does corneal cross-linking last? ›

In simple terms, the younger the patient is at the first cross-linking, the higher the likelihood that they will need a second treatment after 7−8 years. The cornea is completely rebuilt every 7−8 years – a fact that has only recently come to light.

Is corneal refractive therapy covered by insurance? ›

Health insurance usually doesn't cover the cost of refractive or laser eye surgery, but some companies will pay the bill if certain criteria are met. Some insurance companies offer a vision plan which may provide a discounted price or apparent partial coverage for laser eye surgery.

Is corneal cross-linking medically necessary? ›

For members with progressive keratoconus corneal collagen cross-linking is considered medically necessary when all of the following conditions are met: a. Diagnosis of keratoconus based on keratometry and corneal mapping; and b. Any of the following changes have occurred within 24 months: i.

Is cross-linking eye surgery FDA approved? ›

The Food and Drug Administration (FDA) approved Avedro Inc.'s corneal cross-linking system (KXL) for treatment of patients with progressive keratoconus and post-laser in situ keratomileusis ectasia in April 2016.

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